Universität Bonn

Pharma-Zentrum Bonn

de
Henning Hintzsche
© Uni Bonn
Prof. Dr. rer. nat. Henning Hintzsche
Faculty of Agricultural, Nutritional and Engineering Sciences

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Zugehörigkeiten
  • Institute for Nutritional & Food Science
Forschungsschwerpunkte
  • toxicology
  • food science
The research of the AG Hintzsche focuses on detrimental effects of substances found in food. These substances can be of various origins, e.g. contaminants, residues, additives or natural ingredients. Different toxicological methods are being employed with an emphasis on the analysis of DNA damage and DNA repair. The aim is to better understand mechanisms of genotoxic effects and identify strategies for protective measures against such effects. Furthermore, we aim at developing novel approaches for regulatory risk assessment in toxicology.
Ausgewählte Publikationen

H. Reimann, H. Stopper, H. Hintzsche: Fate of micronuclei and micronucleated cells after treatment of HeLa cells with different genotoxic agents. Archives of Toxicology. 97(3), 875-889. 2023

E. Eckert, H. Lepper, H. Hintzsche: Risk assessment of short-term intake of pyrrolizidine alkaloids in food: derivation of an acute reference dose. Food Additives & Contaminants: Part A. 40(4), 588-596. 2023

X. Guo, H. Hintzsche, W. Xu, J. Ni, J. Xue, X. Wang: Interplay of cGAS with micronuclei: Regulation and diseases. Mutation Research - Reviews in Mutation Research. 790, 108440. 2022

H. Reimann, E. Bankoglu, H.  Stopper, H. Hintzsche: In vitro evaluation of chromosomal damage and DNA strand breaks after treatment with the poppy seed alkaloid thebaine. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 870-871, 503393. 2021

H. Reimann, H. Stopper, H. Hintzsche: Long term fate of etoposide‑induced micronuclei and micronucleated cells in Hela‑H2B‑GFP cells. Archives of Toxicology. 94, 3553-3561. 2020

H. Reimann, Q. A. Ngo, H. Stopper, H. Hintzsche: Cytokinesis-block micronucleus assay of celecoxib and celecoxib derivatives. Toxicology Reports. 7, 1588-1591. 2020

H. Reimann, H. Stopper, T. Polak, M. Lauer, M. J. Herrmann, J. Deckert, H. Hintzsche: Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases. Scientific Reports. 10, 22196. 2020

G. Montag, H. Stopper, A. Q. Ngo, H. Hintzsche: Biological activity of the novel vinca alkaloids 4-chlorochablastine and 4-chlorochacristine. Current Cancer Drug Targets. 19(3), 222-230. 2019

Henning Hintzsche
© Uni Bonn
Prof. Dr. rer. nat. Henning Hintzsche
Faculty of Agricultural, Nutritional and Engineering Sciences

Webseite

+49 228 73-2618