Faculty of Medicine
- Institute of Structural Biology
- targetd protein degradation
- smal molecule induced proximity
- molecular glues
- PROTACs
- chemical & structural biology
Tsai, J.M.; *Nowak, R. P.; ; Ebert, B.L.; Fischer, E. S. Targeted protein degradation: from mechanisms to clinic. Nat Rev Mol Cell Biol. 2024. DOI: 10.1038/s41580-024-00729-9
Nowak, R. P.; Ragosta, L.; Huerta, F.; Liu, H.; Ficarro, S. B.; Cruite, J. T.; Metivier, R. J.; Donovan, K. A.; Marto, J. A.; Fischer, E. S.; Zerfas, B. L.; Jones, L. H. Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead. RSC Chemical Biology 2023, 10.1039/D3CB00103B. DOI: 10.1039/D3CB00103B.
*Wang, E. S.; *Verano, A. L.; *Nowak, R. P.; *Yuan, J. C.; Donovan, K. A.; Eleuteri, N. A.; Yue, H.; Ngo, K. H.; Lizotte, P. H.; Gokhale, P. C.; Gray, N. S.; Fischer, E. S. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol 2021, 17 (6), 711-717. DOI: 10.1038/s41589-021-00802-w.
Nowak, R. P.; Xiong, Y.; Kirmani, N.; Kalabathula, J.; Donovan, K. A.; Eleuteri, N. A.; Yuan, J. C.; Fischer, E. S. Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. J Med Chem 2021, 64 (15), 11637-11650. DOI: 10.1021/acs.jmedchem.1c00958.
Nowak, R. P.; DeAngelo, S. L.; Buckley, D.; He, Z.; Donovan, K. A.; An, J.; Safaee, N.; Jedrychowski, M. P.; Ponthier, C. M.; Ishoey, M.; Zhang, T.; Mancias, J. D.; Gray, N. S.; Bradner, J. E.; Fischer, E. S. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol 2018, 14 (7), 706-714. DOI: 10.1038/s41589-018-0055-y.
Faculty of Medicine