Universität Bonn

Pharma-Zentrum Bonn

de
Günther Weindl
© Uni Bonn
Prof. Dr. rer. nat. Günther Weindl
Faculty of Mathematics & Natural Sciences. Board member

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Zugehörigkeiten
  • Pharmaceutical Institute, Department of Pharmakology and Toxicolgy
Forschungsschwerpunkte
  • inflammation
  • pharmacology
  • signal transduction
Our research in experimental pharmacology and cellular signal transduction focusses on understanding the molecular mechanisms of drugs involved in inflammatory and immunological processes. Immunopharmacological concepts, and particularly the characterisation of potentially novel immunomodulatory drugs, such as Toll-like receptor modulators and immunoregulatory peptides, are at the core of our research activities. Current research also focusses on the regulation of inflammatory responses by lysosomotropic drugs and endogenous damage-associated molecular patterns at the molecular level. For our studies, we use human cellular models, including immune cells as well as reconstructed organoid tissue models, which are established and developed as alternative test systems in pharmacological and toxicological research.
Ausgewählte Publikationen

Holze J, Lauber F, Kostenis E, Weindl G (2024) Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling. bioRxiv 2024.01.18.576268

Hopp MT, Holze J, Lauber F, Holtkamp L, Rathod DC, Miteva MA, Prestes EB, Geyer M, Manoury B, Merle NS, Roumenina LT, Bozza MT, Weindl G, Imhof D (2024) Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2. Immunology 171:181-197.

Holze J, Bermudez M, Pfeil EM, Kauk M, Bödefeld T, Irmen M, Matera C, Dallanoce C, De Amici M, Holzgrabe U, König GM, Tränkle C, Wolber G, Schrage R, Mohr K, Hoffmann C, Kostenis E, Bock A (2020) Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling. ACS Pharmacol Transl Sci 3:859-867.

Bockstiegel J, Wurnig SL, Engelhardt J, Enns J, Hansen FK, Weindl G (2023) Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release. Biochem Pharmacol 215:115693.

Müller G, Lübow C, Weindl G (2019) Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells. Autophagy Nov 7:1-16 [Epub ahead of print]

Grabowski M, Murgueitio MS, Bermudez M, Wolber G, Weindl G (2020) The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling. Biochem Pharmacol 171:113687.

Pfalzgraff A, Bárcena-Varela S, Heinbockel L, Gutsmann T, Brandenburg K, Martinez-de-Tejada G, Weindl G (2018) Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo. Br J Pharmacol 175:3581-3593,

Su Q, Weindl G (2018) Glucocorticoids and Toll-like receptor 2 cooperatively induce acute-phase serum amyloid A. Pharmacol Res 128:145-152.
 
 

Günther Weindl
© Uni Bonn
Prof. Dr. rer. nat. Günther Weindl
Faculty of Mathematics & Natural Sciences. Board member

Webseite

+49 228 739103

+49 228 739215

Gerhard-Domagk-Str.3

53121 Bonn