Detection of foreign and harmful nucleic acids by the innate immune system is the central focus of research in the Hartmann lab. Fundamental discoveries about the function of RIG-I in sensing viral RNA has led to a robust program of research in this area and translation to clinical trials with the foundation of the start-up company Rigontec. In addition, the lab also investigates the mechanism and therapeutic potential of several other nucleic acid sensors, namely TLR7/8, TLR9, cGAS, and STING. With the help of the Clinical Study Center and the Central Laboratory of the institute, the lab’s basic research is transferred into clinical application.